Lee’s AI Neuromodulation Lab at Ewha

Link: https://link.springer.com/chapter/10.1007/978-981-95-2070-1_5 Abstract In neuroimaging and neuroscience research, investigating sex differences is crucial for understanding unique aspects of development, behavior, cognitive processes, symptomology, and disease prognosis within the nervous system. While exploring sex differences in neuroimaging requires rigorous scientific standards and often faces criticism [1, 2], such research is essential to enhance representation in

Link: https://pure.ewha.ac.kr/en/publications/circadian-and-multidien-rhythms-of-spikes-and-seizures-in-tempora/ Abstract Sleep and epilepsy share a complex bidirectional relationship. Sleep stages modulate epileptic activity, while epilepsy disrupts sleep architecture. In addition to sleep-stage influences, other cyclic patterns have emerged as key modulators of seizure dynamics. This study aims to (1) characterize the effects of epilepsy on sleep architecture, (2) examine t

Link: https://www.sciencedirect.com/science/article/pii/S1053811925005439 Abstract Transcranial focused ultrasound (tFUS) has emerged as a promising noninvasive technique for brain stimulation due to its precise focusing and deep penetration capabilities. However, its potential to modulate brain networks beyond the stimulation site and optimal sonication parameters required for such modulation remain unclear. In light of this knowledge gap, this study investigates the effects

Link: https://www.nature.com/articles/s41598-024-81158-8 Abstract Individual differences in sleep duration have been reported, and genetic components of sleep duration have been identified showing various heritability. To identify genetic variants that contribute to sleep duration, we conducted a human genome-wide identification on sleep duration and performed confirmatory experiments using a Drosophila model. Genome-wide association study in human was analyzed to determine t

Link: https://www.mdpi.com/2072-6643/16/24/4266 Abstract Background Sleep, a process physiologically vital for mental health, faces disruptions in various sleep disorders linked to metabolic and neurodegenerative risks. Zizyphus seed (Zizy) has long been recognized for its diverse pharmacological attributes, including analgesic, sedative, insomnia, and anxiety alleviation. Objectives In this study, the sleep-prolonging effects of Zizy extract (100, 200 mg/kg), along with thei

Link: https://onlinelibrary.wiley.com/doi/full/10.1111/acer.15449 Abstract Background Alcohol withdrawal is widely recognized as a trigger for acute symptomatic seizures among individuals with chronic alcohol consumption. While most alcohol withdrawal seizures occur shortly after cessation, chronic alcohol consumption can be associated with the development of epilepsy, necessitating anti-epileptic drug (AED) therapy. This study aimed to investigate the clinical characteristic

Link: https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.123.045393 Abstract BACKGROUND We aimed to investigate the association between a diagnosis of untreated unruptured intracranial aneurysms (UIAs) and the development of mental illness. METHODS This retrospective, propensity-score-matched cohort study was based on the nationwide South Korean database. The UIA diagnosis group included participants newly diagnosed with UIA between 2011 and 2019. For a well-matched contr

Link: https://direct.mit.edu/imag/article/doi/10.1162/imag_a_00216/122597 Abstract Diversity, equity, and inclusivity (DEI) are important for scientific innovation and progress. This widespread recognition has resulted in numerous initiatives for enhancing DEI in recent years. Although progress has been made to address gender and racial disparities, there remain biases that limit the opportunities for historically under-represented researchers to succeed in academia. As membe

Link: https://link.springer.com/chapter/10.1007/978-981-97-0130-8_27 Abstract Sleep is a fundamental physiological process that plays a vital role in maintaining overall health and well-being. Over the past few decades, research has highlighted intriguing sex differences in various aspects of sleep, including sleep architecture, sleep-wake regulation, sleep disorders, and the impact of sleep on health outcomes. It is crucial to understand the various factors affected by sex d

Link: https://link.springer.com/article/10.1007/s12028-023-01889-w Abstract Background Status epilepticus (SE) is a critical neurological emergency in patients with neurological and nonneurological diseases. Mortality rises with SE severity. However, whether brain injury or systemic organ dysfunction causes death after SE remains unclear. We studied clinical outcomes and systemic dysfunctions associated with SE using standardized data from the common data model. This model in